A new antitumor antibiotic, spergualin: Isolation and antitumor activity.
نویسندگان
چکیده
منابع مشابه
Antitumor activity of a new antitumor antibiotic, stubomycin.
The antitumor activity of a new antibiotic, stubomycin, against various murine tumors was studied. Stubomycin showed antitumor activity against Sarcoma 180, IMC-carcinoma and Meth-A tumor. In particular, all of the mice inoculated i.p. with IMC-carcinoma were cured when they were given nine successive injections of stubomycin. Stubomycin also showed remarkable antitumor effects against Sarcoma ...
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Sir: During our studies of antitumor antibiotics, spergualin was discovered in culture filtrates of a Bacillus strain.') Spergualin showed a marked inhibition against experimental mouse tumors, and the structure was determined to be (-)(I 5S)-1-aminol9-guanidino-11,15-dihydroxy-4, 9,12-triazanonadecane-10,13-dione2>. In thiscommunication, we report the synthesis of epimeric spergualin (1) and e...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1981
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.34.1619